منابع مشابه
Pathogens
A long-standing question in immunity is how the host detects pathogens. Since many microbes are also beneficial for the host, accurate discrimination between non-pathogens and pathogens is important. Traditionally, the microbe-associated molecular patterns (MAMPs) are thought to induce the innate immune response via the Toll-like receptor signaling. Since many patho-genic as well as nonpathogen...
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As we approach the second anniversary of the launch of PLoS Pathogens, it is evident that the journal has rapidly established itself as an important publication in the field of pathogen–host interactions (Image 1). We attribute this success to the commitment and motivation of our talented editorial board, to a receptive community (Table 1) who sees this as a leading open-access journal, and to ...
متن کاملThe "histone mimicry" by pathogens.
One of the defining characteristics of human and animal viruses is their ability to suppress host antiviral responses. Viruses express proteins that impair the detection of viral nucleic acids by host pattern-recognition receptors, block signaling pathways that lead to the synthesis of type I interferons and other cytokines, or prevent the activation of virus-induced genes. We have identified a...
متن کاملThe search for unrecognized pathogens.
The distribution and diversity of microorganisms in the world are far greater than have been previously appreciated. Molecular, cultivation-independent methods have played a key role in this insight. To what extent do humans remain ignorant of microbial diversity within the human body and the settings in which microorganisms cause human disease? In addition to implicating microbial agents in no...
متن کاملNoroviruses: the perfect human pathogens?
Noroviruses are perhaps the perfect human pathogens. These viruses possess essentially all of the attributes of an ideal infectious agent: highly contagious, rapidly and prolifically shed, constantly evolving, evoking limited immunity, and only moderately virulent, allowing most of those infected to fully recover, therebymaintaining a large susceptible pool of hosts. These characteristics have ...
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ژورنال
عنوان ژورنال: Journal of Clinical Virology
سال: 2007
ISSN: 1386-6532
DOI: 10.1016/s1386-6532(07)70003-3